Lead generation libraries
Bespoke Lead Generation Arrays. Chemical arrays of between 100 – 500 members can be prepared around pharmaceutically acceptable templates, and designed to have a range of drug-like and lead-like properties. These can be prepared using parallel synthesis techniques already developed with Sygnature’s chemistry group. 
 
Enantioselective synthesis and chiral resolutions
A large number of discovery programs will involve chiral molecules at some stage.  Sygnature has considerable expertise in stereoselective synthesis and the resolution of chiral compounds.  Using well developed protocols we can analyse and resolve materials using a variety of techniques such as chiral HPLC, NMR and classical resolutions.

Hit-to-lead projects
During the hit-to-lead process, analogues of chemical hits are synthesised in an effort to improve properties such as potency, selectivity against other biological targets, and ADME parameters. These analogues are structurally related to the original hit, and will be synthesised often by the same chemistry using parallel semi-automated approaches.
 
Lead optimisation
Once validated chemical leads are identified within a project then a much more focused approach is adopted to prepare very close analogues designed to probe important structural features of the molecule.  Smaller numbers of compounds are prepared which ask specific questions about the interactions between the biological target and the molecule of interest.  The objective of this type of work is to optimise the properties to allow the further testing of compounds in advanced disease models. 
 
Computational Chemistry and Structure-based design
In collaboration with CCR computational resources we can offer molecular modelling support for your project whatever stage it is at.  For further information click here
 
Compound handling and storage
Post synthetic manipulation of compounds such as preparation of screen ready plates, dilution, storage and shipping can all be handled through Sygnature CS to make a seamless transition from concept to biological data.