During the hit-to-lead process, analogues of chemical hits are synthesised in an effort to improve properties such as potency, selectivity against other biological targets, and ADME parameters. These analogues are structurally related to the original hit, and will be synthesised often by the same chemistry using parallel semi-automated approaches.
Our arrays are;
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Typically 30 - 250 compounds
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Computationally designed to be lead-like
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10-30 mg isolated material (sufficient for parallel selectivity screening and early ADME screens)
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Often complex building block synthesis required
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>90% pure, LC-MS & NMR
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Shipped in screen ready format
